2010 Summer Program on Semiparametric Bayesian Inference: Applications in Pharmacokinetics and Pharmacodynamics
Workshop Information
Description of Activities
The program began with a week of tutorials and workshop activities. There were extended, tutorial-style talks during morning sessions, and contributed and invited research talks during the afternoons. Afternoon talks were selected to complement topics covered in the morning sessions.
At the end of the first week workshop research working groups were formed. The working groups tackled particular research problems in the area. Working group activities included workshop-style presentations by group members to stimulate discussion on specific issues. Themes for the working groups and workshop sessions:
- semi-parametric population PK/PD models
- dose individualization
- probability models for PK/PGx networks
- joint inference for PK and PD data
Schedule
Monday, July 12, 2010
Radisson RTP
Tutorials
| 8:00-8:45 a.m. | Registration and Continental Breakfast |
| 8:45-9:00 | Welcome & Overview |
| 9:00-10:45 | Tutorial 1 Wes Johnson, Univ. of California-Irvine and David Dunson, Duke University Bayesian Nonparametrics: An Overview |
| 10:45-11:15 | Break |
| 11:15-12:30 | Tutorial 1, continued |
| 12:30-1:30 | Lunch |
| 1:30-3:00 | Tutorial 2 David D'Argenio, University of Southern California and Paolo Vicini, Pfizer Pharmacokinetics (PK) and Pharmacodynamics (PD) |
| 3:00-3:30 | Break |
| 3:30-5:00 | Tutorial 2, continued |
Tuesday, July 13, 2010
Radisson RTP
Opening Workshop
| 8:00-9:00 a.m. | Registration and Continental Breakfast |
| 9:00-Noon | Prior Elicitation and Construction |
| 9:00-9:45 | Wes Johnson, Univ. of California-Irvine On the Value of Incorporating Scientific Input in Modeling and Data Analysis, and How to Do it Without (too much) Pain |
| 9:45-10:30 | Peter Thall, MDACC Prior Elicitation in Bayesian Clinical Trial Design |
| 10:30-11:00 | Break |
| 11:00-11:45 | Siva Sivaganesan, University of Cincinnati Sample Size: How Many Subjects |
| 11:45-12:00 | Discussion |
| Noon-1:00 | Lunch |
| 1:00-2:30 | Lang Li, Indiana University and Paolo Vicini, Pfizer Identifiability and Prior Regularization: A PK-PD Modeling View |
| 2:30-3:00 | Break |
| 3:00-3:45 | Robert Leary, Pharsight Computational Challenges of Nonlinear Mixed Effects Analysis for PK/PD Modeling |
| 3:45-4:30 | Sujit Ghosh, N.C. State University Application of Nonlinear Mixed Models Involving ODEs |
| 4:30-5:00 | Discussion |
Wednesday, July 14, 2010
Radisson RTP
| 8:00-9:00 a.m. | Registration and Continental Breakfast |
| 9:00-Noon | Joint PK and PD |
| 9:00-9:45 | Wojciech Krzyzanski, State University of New York PD/PD Modeling of Therapeutic Effects of Erythropoietin |
| 9:45-10:30 | Michele Guidani, University of New Mexico NP Bayes Functional Regression for a PK/PD Semi-Mechanistic Model |
| 10:30-11:00 | Break |
| 11:00-11:45 | Thanasis Kottas, Univ. of California-Santa Cruz A Bayesian Nonparametric Modeling Approach for Developmental Toxicology Data |
| 11:45-12:00 | Discussion |
| Noon-1:00 | Lunch |
| 1:00-2:30 | David Conti, University of Southern California; Duncan Thomas, University of Southern California Bayesian Hierarchical and PD/PK Modeling for Complex Pathways in Molecular Epidemiology |
| 2:30-3:00 | Mike Reed, Duke University Why Metabolism is a Challenge for Statistical Analysis: the Case of Substrate Inhibition |
| 3:00-3:30 | Break |
| 3:30-4:15 | Peter Mueller, MD Anderson Nonparametric Bayesian Models for Population PK/PD |
| 4:15-5:00 | Donatello Telesca, Univ. of California-Los Angeles Modeling Pk/PGx Data |
| 5:00-5:30 | Discussion |
Thursday, July 15, 2010
Radisson RTP
| 8:00-8:45 a.m. | Registration and Continental Breakfast |
| 9:00-12:30 | DDP, Mixture Models and Related Models |
| 9:00-9:45 | Subharup Guha, University of Missouri Posterior Simulation in Countable Mixture Models for Large Data Sets |
| 9:45-10:30 | Steve MacEachern, Ohio State University Nonparametric Bayesian Models for Related Subpopulations |
| 10:30-11:00 | Break |
| 11:00-11:45 | Maria de Iorio, Imperial College Nonparametric Approaches for Heterogeneous Longitudinal Data |
| 11:45-12:30 | Tatiana Tatarinova, University of Glamorgan Analysis of Biological Time Series Data in Data-Rich Situations |
| 12:30-1:30 | Lunch |
| 1:30-2:10 | Roger Jelliffe, University of Southern California Tools for Individualizing Drug Dosage Regimens for Patients |
| 2:10-2:50 | William Gillespie, Metrum Institute Examples of Decison-Focused Modeling and Simulation in Clinical Drug Development and Some Methodology R&D Opportunities They Suggest |
| 2:50-3:30 | Gary Rosner, Johns Hopkins University Optimal Design with Bayesian Nonparametric Priors |
| 3:30-4:00 | Break |
| 4:00-5:00 | David D'Argenio, University of Southern California; William Gillespie, Metrum Institute; Roger Jelliffe, University of Southern California; Bob Leary, Pharsight Implementation and Available Software |
| 5:00-5:30 | Poster Advertisement Session: 2 minute ads by each poster presenter |
| 6:00-8:00 | Poster Session and Reception SAMSI will provide poster presentation boards and tape. The board dimensions are 4 ft. wide by 3 ft. high. They are tri-fold with each side being 1 ft. wide and the center 2 ft. wide. Please make sure your poster fits the board. The boards can accommodate up to 16 pages of paper measuring 8.5 inches by 11 inches. |
| 8:00- | Informal Debate: Parametric PD Models vs. Nonparametric PD Models |
Friday, July 16, 2010
Radisson RTP
| 8:00-9:00 a.m. | Registration and Continental Breakfast |
| 9:00-12:15 | Nonparametric Bayes and Clustering for Random Effects Distributions: |
| 9:00-9:45 | David Dahl, Texas A&M University Strategies for Incorporating Prior Information in Random Partition Models with Examples |
| 9:45-10:30 | Mahlet Tadesse, Georgetown University Stochastic Partitioning and Model-based Clustering with Variable Selection |
| 10:30-11:00 | Break |
| 11:00-11:45 | Julien Cornebise, University of British Columbia Inference for Mixed Effects Stochastic Differential PKPD Models with Particle MCMC |
| 11:45-12:15 | Gary Rosner, Johns Hopkins University and Peter Mueller, University of Texas Summary and Discussion |
| 12:15-1:30 | Lunch |
| 1:30-2:30 | Formation of Working Groups |
| 2:30-3:00 | Break |
| 3:00-4:00 | Initial Discussions |
Monday, July 19 - Thursday, July 22
SAMSI, RTP, Rooms 104, 150, 201, 203, 259
Monday, July 19
William Gillespie, Metrum Institute
Part II of Examples of Decison-Focused Modeling and Simulation in Clinical Drug Development and Some Methodology R&D Opportunities They Suggest
Tuesday, July 20
Susie Bayarri, University of Valencia
Dealing with Uncertainty in Mechanistic Models 101
Working Groups
Themes:
- Identifiability and Prior Regularization
- Joint PK and PD Modeling
- PK/PD Simulation for Design and Dose Individualization
- Pharmacogenomics and Networks
- Nonparametric Bayes and Clustering for PK and PD Population Analysis
| 12:00-1:30 | Lunch |
Friday, July 23
SAMSI
| 9:30-12:00 | Presentations by working groups and discussion about future projects |
| 12:00-1:30 | Lunch |
| 1:30 | Adjourn |