Registration and Continental Breakfast

9:00-9:45          Statistics & Data Analysis

                                Tom Kepler, Duke University

9:45-10:30        Bioinformatics and Genomics

                         Tom Kepler, Duke University

10:30-11:00      Coffee Break

11:00-11:45      Epidemiology

                         Alun Lloyd, North Carolina State University

11:45-12:30      Mathematical modeling & simulation

                         Tom Kepler, Duke University

Lunch

Biology tutorials:

1:30-2:30          Molecular Evolution

                          Jeff Thorne, North Carolina State University

2:30-3:00          Coffee Break

3:00-4:00          Microbiology

                          Denise Kirschner, University of Michigan

4:00-5:00          Immunology

                          Lindsay Cowell, Duke University

Registration and Continental Breakfast

Welcome

• Jim Berger, SAMSI

• Denise Kirschner, University of Michigan

• Lindsay Cowell, Duke University

Opening Address

• Tom Kepler, Duke University

SESSION 1:  Biostatistics, Epidemiology and Public Health

Session Chair:  Andrew Nobel, University of North Carolina - Chapel Hill

�Markov Models for Characterizing the Development of HIV Resistance Mutations�

Victor De Gruttola, Harvard School of Public Health

�Stochastic Models and Analytic Issues for Interventions against Pandemic Influenza�

M. Elizabeth Halloran, Emory University  

Lunch

�From Immunome to Vaccine: Using Immunoinformatics to Design New Vaccines�

Anne De Groot, Brown University 

�New Paradigm for Management of Tropical Diseases�

Ayoade Oduola, World Health Organization

Coffee Break

Session Chair:  Tim Elston, University of North Carolina - Chapel Hill

DISCUSSION:  Mathematical challenges in biostatistics and public health

Discussion Leaders

• Alun Lloyd, North Carolina State University

• Anthony So, Duke University (presentation)

Introductions to poster session

8:30-9:00 AM

Registration and Continental Breakfast

SESSION 2:  Microbiology, Microbial Ecology & Evolution, Microbial Genomics

Session Chair:  Andrew Nobel, University of North Carolina - Chapel Hill

"Use of repetitive DNA in Helicobacter pylori for persistence in human hosts"

Martin Blaser, New York University

Coffee Break

"Predicting the Future Evolution of Human Influenza Viruses"

Walter Fitch, University of California-Irvine

Lunch

Session Chair:  Scott Schmidler, Duke University

"Bioinformatic Methods for Virulence Gene Prediction in Microbial Pathogens"

Joanna Fueyo, IBM

"A Mathematical Model for Nutrient Depletion and Detachment in a Heterogeneous Biofilm"

Jorge Velasco-Hernandez, Instituto Mexicano del Petroleo

Coffee Break

"Modeling Long-Term HIV Dynamics and Antiviral Treatment with Consideration of Pharmacokinetics, Adherence and Drug Susceptibility"

Hulin Wu, University of Rochester

Panel Discussion: "Mathematical challenges in microbiology"

Discussion Leader

• Denise Kirschner, University of Michigan

SESSION 3:  Immunology

Session Chair:  Alun Lloyd, North Carolina State University

"Monoclonal Antibodies in the Treatment of Disease:  Modeling How They Couple Target Cell to Killer Cells"

Byron Goldstein, Los Alamos National Laboratory

"MHC Polymorphism and Peptide Diversity"

Rob De Boer, Utrecht University

Coffee Break

"A Bioinformatics Approach to the Antigen Presentation and Processing Pathways"

Can Kesmir, Utrecht University

Lunch

Session Chair:  Scott Schmidler, Duke University

Panel Discussion:  "Mathematical Challenges in Immunology and Systems Biomedicine"

Discussion Leaders

Lindsay Cowell, Duke University

Denise Kirschner, University of Michigan

Coffee Break

Charge to the participants and final words

Tom Kepler, Duke University

Working Group Formation and Planning