Opening Workshop: August 13 – 17, 2018

** Deadline for this workshop was June 18, 2018. **

Location

This workshop will be held at SAS Hall on the campus of NC State University.

Description

The SAMSI PMED program will bring together mathematical, statistical, computational, and biomedical scientists with the goal of forging innovative advances in data-driven, quantitative methodology for precision medicine. This workshop will provide a foundation for the year’s activities by highlighting the diverse range of perspectives on and approaches to precision medicine among quantitative and health sciences researchers through three-and-one-half days of methodological and applied talks by leading scientists. The workshop will begin with a featured lecture by Dr. Norman (Ned) Sharpless, Director of the National Cancer Institute, who will present his views on the role of the quantitative sciences in cancer precision medicine.

On Thursday afternoon, a Working Groups formation session will take place in which leaders of proposed program-long Working Groups will
make brief presentations on the themes and objectives of the groups. Organizational meetings of each group will follow. These discussions will continue through Fridaymorning, and the workshop will adjourn at lunchtime. Group topics/themes are tentative at this time; some proposed topics include Integrated Modeling Strategies, Improved Data-Driven Sequential Decision-Making, Uncertainty Quantification for Precision Medicine, Methodology for mHealth, and Research-Practice Gaps.

Schedule and Supporting Media

Printed Schedule
Speaker Abstracts
Poster Session Titles
Participant List

Lecturers

Confirmed Speakers currently include:

Monday, August 13, 2018
SAS Hall Room 2203, NC State University, Raleigh, NC

Description Speaker Slides Videos
Registration
Welcome and Introductory Information SAMSI Directorate & PMED Organizers
Keynote: Moving from Big Data to Big Insights: Data Science as the Cornerstone of a Learning Health System Michael Pencina, Duke University
Harnessing Patient-generated Health Data for Precision Medicine Arlene Chung, University of North Carolina at Chapel Hill (UNC-CH)
Contextual, Intelligent Experiences at Cerner Corporation Andrew Roberts, Cerner Corporation
Infectious Diseases Chair: Ruian Ke, Los Alamos & North Carolina State University (NCSU)
Beyond ART: towards eradication or drug-free control of HIV infection David Margolis, UNC-CH HIV Cure Center, UNC Institute of Global Health and Infectious Diseases
Individual Variability or Just Variability? Ruy Ribeiro, University of Lisbon
Dynamics and Implications of Hepatitis B Virus Infection Yang Kuang, Arizona State University
US FDA Perspectives on Precision Medicine Moderator: Lisa LaVange, UNC-CH
Panelists: Laura Lee Johnson, US FDA
Sirisha Mushti, US FDA
Shiowjen Lee, US FDA/CBER

Tuesday, August 14, 2018
SAS Hall Room 2203, NC State University, Raleigh, NC

Description Speaker Slides Videos
Machine Learning and Precision Medicine Chair: Michael Kosorok, UNC-CH
Inference on Individualized Treatment Rules from Observational Studies with High-Dimensional Covariates Yingqi Zhao, Fred Hutchinson Cancer Research Center
Bayesian Generative Adversarial Networks Andrew Wilson, Cornell University
A Sequential Conditional Test for Treatment by Covariate Interactions Min Qian, Columbia University
Confounding-robust Policy Improvement Nathan Kallus, Cornell University
Learning to Tailor Treatments using Observational Data Chairs: Erica Moodie, McGill University
Dan Lizotte, University of Western Ontario
Credible Ecological Inference for Medical Decisions with Personalized Risk Assessment Charles Manski, Northwestern University
Measurement Error and Precision Medicine Michael Wallace, University of Waterloo
Building a Machine Learning Health System Nigam Shah, Stanford University
What is the biggest challenge to using observational data for precision medicine that we should tackle next? Panel Discussion
Moderator: Erica Moodie, McGill University
Panelists: Michael Wallace, University of Waterloo
Charles Manski, Northwestern University
Maria Mayorga, NCSU
Nigam Shah, Stanford University
Poster Session and Reception

Wednesday, August 15, 2018
SAS Hall Room 2203, NC State University, Raleigh, NC

Description Speaker Slides Videos
Tumor Immunology Chair: Heiko Enderling, Moffitt Cancer Center
Regrowth Rates of Tumors after Radiation Vary Depending on Differences in Patient Immune Systems: a compartment model Dorothy Wallace, Dartmouth College
Math and its Application in Oncology Andrew Wang, UNC-CH
The Immune Checkpoint Kick Start: Optimization of Neoadjuvant Combination Therapy using Game Theory Alexander Anderson, Moffitt Cancer Center
Local and Systemic Consequences of Radiation Therapy Heiko Enderling, Moffitt Cancer Center
Clinical Trials and Precision Medicine Chair: Eric Laber, NCSU
Sample Size Considerations for Precision Medicine Eric Laber, NCSU
New Bayesian Clinical Trial Designs to Evaluate Precision Medicine Peter Thall, MD Anderson Cancer Center
Estimating Causal (Personalized) Effects from a Randomized Clinical Trial when Noncompliance is Measured with Error David Vock, University of Minnesota
Personalized Radiotherapy Planning for Glioma using Multimodal Scans and Model Calibration John Lowengrub, University of California, Irvine
Introduction to Working Groups

Thursday, August 16, 2018
SAS Hall Room 2203 & Second Floor Classrooms, NC State University, Raleigh, NC

Break out Classrooms:

Description Speaker Slides Videos
Sequential Decision Making Chair: Ambuj Tewari, University of Michigan
Reinforcement Learning for a Population of Users Ambuj Tewari, University of Michigan
Optimized Personalized Behavioral Interventions using System Identification and Control: Two Illustrative Examples Daniel Rivera, Arizona State University
Using Systems Engineering to Inform Public Health Policies: The Impact of Insurance Expansion on Colorectal Cancer Screening Maria Mayorga, NCSU
Keynote: Data: where Precision Oncology and Learning Health meet Warren Kibbe, Duke University
Working Group Formations
SAS 2102, (seats 40)
SAS 2106, (seats 44)
SAS 2225, (seats 48)
SAS 2229, (seats 48)
SAS 2235, (seats 52)

Friday, August 17, 2018
SAS Hall Room 2203 & Second Floor Classrooms, NC State University, Raleigh, NC

Break out Classrooms:

Description Speaker Slides Videos
Working Group Formations
SAS 2102, (seats 40)
SAS 2106, (seats 44)
SAS 2225, (seats 48)
SAS 2229, (seats 48)
SAS 2235, (seats 52)
Wrap-Up
Shuttle to RDU Airport

Questions: email [email protected]