Wednesdays, 4:30-7:00pm at SAMSI, Research Triangle Park, NC, beginning Wednesday, January 9, 2019. Last Class: Wednesday, April 24, 2019.
Instructors: This course will be jointly taught by multiple instructors; lead instructor is Marie Davidian, PJ Stuart Hunter Distinguished Professor of Statistics, N.C. State University. Additional Instructor is: Eric Laber, Associate Professor of Statistics, N.C. State University.
This course is being offered in conjunction with the SAMSI year-long research Program on Statistical, Mathematical, and Computational Methods for Precision Medicine (PMED).
This course will provide a comprehensive introduction to methodology for data-based development and evaluation of dynamic treatment regimes. A dynamic treatment regime is a set of sequential decision rules, each corresponding to a key point in a disease or disorder process at which a decision on the next treatment action must be made. Each rule takes patient information to that point as input and returns the treatment s/he should receive from among the available options, thus tailoring treatment decisions to a patient’s individual characteristics. Methods will be motivated and developed through a formal time-dependent causal inference framework. Examples will be drawn from cancer and other chronic disease research and research in the behavioral, educational, and other sciences.
- NCSU – MA 810.001
- UNC-CH -STOR 894.001 / MATH 892.001
- Duke – STA 790.01 / MATH 790-71-01
|Jan 9||Introduction and Preliminaries: Basic Causal Inference||Marie Davidian|
|Preliminaries: Basic Causal Inference||Marie Davidian|
|** Homework Assignment (Chapters 1-3) **|
|** Data for Homework Assignment **|
|** Homework due date is February 6, 2019 **|
|Jan 16||Preliminaries: Basic Causal Inference [cont.]||Marie Davidian||Single Decision Treatment Regimes: Fundamentals||Marie Davidian|
|Jan 23||Single Decision Treatment Regimes: Fundamentals [cont.]||Marie Davidian|
|Jan 30||Single Decision Treatment Regimes: Fundamentals [cont.]||Marie Davidian||Single Decision Regimes: Additional Methods||Marie Davidian|
|Feb 6||Single Decision Regimes: Additional Methods [cont.]||Marie Davidian|
|Feb 13||Multiple Decision Treatment Regimes: Fundamentals||Marie Davidian|
|Feb 20||Multiple Decision Treatment Regimes: Fundamentals [cont.]||Marie Davidian|
|Feb 27||Multiple Decision Treatment Regimes: Fundamentals [cont.]||Marie Davidian|
|Mar 6||Optimal Multiple Decision Treatment Regimes||Marie Davidian|
|Mar 13||** NO CLASS – Spring Break **|
|Mar 20||Optimal Multiple Decision Treatment Regimes [cont.]||Marie Davidian|
|Mar 27||Optimal Multiple Decision Treatment Regimes [cont.]||Marie Davidian|
|Apr 3||Sequential Multiple Assignment Randomized Trials (SMARTs)||Eric Laber|
|Apr 10||Sequential Multiple Assignment Randomized Trials (SMARTs) [cont.]||Eric Laber|
|Apr 17||Statistical Inference for Treatment Regimes||Eric Laber|
|Apr 24||Statistical Inference for Treatment Regimes [cont.]||Eric Laber|
Questions: email firstname.lastname@example.org