19 T.W. Alexander Drive P.O.Box 14006 Research Triangle Park, NC 27709-4006 Tel: 919.685.9350 Fax: 919.685.9360 [email protected]

Subgroups Analysis
A Working Group in Multiplicity and Reproducibility in Scientific Studies

Group Leaders: Juliet Shaffer (University of California-Berkeley), Siva Sivaganesan (University of Cincinnati)

Password Protected Site (future)

Announcements

Meeting Time: Daily 1:00 - 2:45, July 13 - 26, 2006
Location: NISS building, 2nd floor conference room

Remote access for the meeting is available:
Via teleconference at 919-685-9338

Note: Until we can get the needed bandwidth, equipment, etc. for broadcasting meetings via a webcam, SAMSI will be employing the following process for remote participation in working groups. A webcam picture will be available for viewing during the meetings. However, for audio, participants will have to call into the conference line.

Meeting Activities

Date	Topics & Readings	Notes
July 13, 2006	Summary of Subgroup Analysis working group, notes from July 13, 2006	Papers: EU Multiplicity Points (pdf), Article by Pocock, et al 2002 in Statistics and Medicine (pdf)
July 14, 2006	Summary of Subgroup Analysis working group, notes from July 14, 2006	Papers: Subgroup analysis article from Lancet 2005 (pdf), Subgroup analysis in clinical trials by Cook, et al 2004 (pdf)
July 17, 2006	Search Results of Subgroup Analysis working group, from July17, 2006	Papers: Subgroup analysis article from Lancet 2000 (pdf), CONSORT statement paper from Lancet 2001 (pdf)
July 18, 2006	Summary of Subgroup Analysis working group, notes from July 18, 2006	Papers: Article by Brookes et al Subgroup analyses in randomized controlled trials, 2001 (pdf)
July 19, 2006	Tentative Titles and Abstracts Summary of Subgroup Analysis working group, notes from July 19, 2006	Presentation from Opening Workshop by Bob Obenchain, Eli Lilly and Company: Identifying Meaningful Patient Subgroups (slides)
July 20, 2006	Presentation by Bob Obenchain, Eli Lilly and Company: “Two Simulation Case-Studies Illustrating "Local Control" Analyses” (Slides)	Papers: Article by Wainer and Brown (2004) “Three Statistical Paradoxes in �the Interpretation of Group Differences: Illustrated with Medical School Admission and Licensing Data” (pdf)
July 21, 2006
July 24, 2006	Subgroup Analysis working group draft (doc)	Paper: Klockars and Hancock (1998) “A More Powerful Post Hock Multiple Comparison Procedure in Analysis of Variance” (pdf)
July 25, 2006	Summary of Subgroup Analysis working group, notes from July 25, 2006	Presentation from Opening Workshop: by Steven Goodman: “Non-replicating comments on replication” (Slides)
July 26, 2006	Presentation by Prakash Laud, Medical College of Wisconsin, Division of Biostatistics: “What can BNP do for subgroup analysis?” (Slides)
July 27, 2006	Subgroup Analysis working group draft (doc)
July 28, 2006	Transition Workshop Day 10:00 - 10:45 “Adaptive Hypothesis Testing Intervals: a Calibration of p-values for Large Samples” Luis Pericchi, University of Puerto Rico, Rio Piedras 10:45 – 11:30 “Subgroup Analysis - a Stylized Bayes Approach” Siva Sivaganesan, University of Cincinnati 11:45 - 12:15 Comments from the Subgroup Analysis Working Group Juliet Shaffer, University of California-Berkeley 12:15-13:00 Comments from the Reproducibility Working Group Stan Young, NISS and Bob Obenchain, Eli Lilly and Company 13:00 - 14:00 Lunch 14:00 Final discussion, Open floor

Group Members

Name	Affiliation	Email Address
Ramin Arani	Bristol-Myers Squibb Company	[email protected]
Jim Berger	SAMSI	[email protected]
Bob Obenchain	Eli Lilly and Company	[email protected]
Abel Rodriguez	Duke University	[email protected]
Gary Rosner	University of Texas M.D. Anderson Cancer Center	[email protected]
James Scott	Duke University	[email protected]
Juliet Shaffer	University of California-Berkeley	[email protected]
Siva Sivaganesan	University of Cincinnati	[email protected]
Lei Sun	University of Toronto	[email protected]
Rochelle Tractenberg	Georgetown University School of Medicine	[email protected]
Prakash Laud	Medical College of Wisconsin, Division of Biostatistics	[email protected]
David Siroky	Duke University, Department of Political Science	[email protected]
Marianthi Markatou	Department of Biostatistics, Mailman School of Public Health, Columbia University	[email protected]

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