19 T.W. Alexander Drive P.O.Box 14006 Research Triangle Park, NC 27709-4006 Tel: 919.685.9350 Fax: 919.685.9360 info@samsi.info

Multiple Testing
A Working Group in Multiplicity and Reproducibility in Scientific Studies

Group Leaders: Peter Mueller (University of Texas, M.D. Anderson Cancer Center)

Password Protected Site (future)

Announcements

Meeting Time: Daily 10:00 - 11:45, July 13 - 27, 2006
Location: NISS building, 2nd floor conference room

Remote access for the meeting is available:
Via teleconference at 919-685-9338

Note: Until we can get the needed bandwidth, equipment, etc. for broadcasting meetings via a webcam, SAMSI will be employing the following process for remote participation in working groups. A webcam picture will be available for viewing during the meetings. However, for audio, participants will have to call into the conference line.

Meeting Activities

Date	Topics & Readings	Notes
July 13, 2006	Presentation by Helmut Finner, Institute of Biometrics & Epidemiology, German Diabetes Center, Dusseldorf on Dependency and False Discovery Rate: Asymptotics
July 14, 2006	Presentation  by Lei Sun, University of Toronto
July 17, 2006	Presentation by Valen Johnson, M.D. Anderson Cancer Center on Bayesian Multiple Testing Based on Test Statistics
July 18, 2006
July 19, 2006	Presentation by Yoav Benjamini, Tel Aviv University: "Some thoughts on Replicability Issues in Science" (Abstract) (Slides)
July 20, 2006	Presentation by J. T. Gene Hwang, Cornell University: “How to improve on t–tests or F–tests for a large number of hypotheses? Shrink both the means and variances!” (Abstract) (Slides)
July 21, 2006
July 24, 2006	Presentation by Ken Rice, University of Washington: “Models with Robustness to Outliers” (slides)
July 25, 2006
July 26, 2006	Presentation by James Scott, Duke University: “Differential Expression in Megakaryocyte vs. Erythroblast: A Case Study in Hierarchical Modeling for Microarrays” (slides)
July 27, 2006	Presentation by Peter Mueller, University of Texas M.D. Anderson Cancer Center: “FDR and Bayesian Decision Rules” (handout)
July 28, 2006	Transition Workshop Day 10:00 - 10:45 “Adaptive Hypothesis Testing Intervals: a Calibration of p-values for Large Samples” Luis Pericchi, University of Puerto Rico, Rio Piedras 10:45 – 11:30 “Subgroup Analysis - a Stylized Bayes Approach” Siva Sivaganesan, University of Cincinnati 11:45 - 12:15 Comments from the Subgroup Analysis Working Group Juliet Shaffer, University of California-Berkeley 12:15-13:00 Comments from the Reproducibility Working Group Stan Young, NISS and Bob Obenchain, Eli Lilly and Company 13:00 - 14:00 Lunch 14:00 Final discussion, Open floor

Group Members

Name	Affiliation	Email Address
Ramin Arani	Bristol-Myers Squibb Company	ramin.arani@bms.com
Susie Bayarri	University of Valencia	susie.bayarri@uv.es
Jim Berger	SAMSI	berger@samsi.info
Thorsten Dickhaus	German Diabetes Center	dickhaus@ddz.uni-duesseldorf.de
Helmut Finner	German Diabetes Center	finner@ddz.uni-duesseldorf.de
Michele Guindani	University of Texas M.D. Anderson Cancer Center	mguindani@mdanderson.org
Telba Irony	Center for Devices and Radiological Health - FDA	telba.irony@fda.hhs.gov
Woncheol Jang	Duke University	wjang@stat.duke.edu
Jiashun Jin	Purdue University	jinj@stat.purdue.edu
Valen Johnson	University of Texas M.D. Anderson Cancer Center	vejohnson@mdanderson.org
Vered Madar	Tel-Aviv University	madar@post.tau.ac.il
Peter Mueller	University of Texas M.D. Anderson Cancer Center	pm@odin.mdacc.tmc.edu
Jing Qiu	University of Missouri-Columbia	qiujing@missouri.edu
Kenneth Rice	University of Washington	kenrice@u.washington.edu
Abel Rodriguez	Duke University	abel@isds.duke.edu
Gary Rosner	University of Texas M.D. Anderson Cancer Center	glrosner@mdanderson.org
Sanat Sarkar	Temple University	sanat@temple.edu
James Scott	Duke University	js577@cam.ac.uk
Juliet Shaffer	University of California-Berkeley	shaffer@stat.berkeley.edu
Siva Sivaganesan	University of Cincinnati	sivagas@ucmail.uc.edu
Lei Sun	University of Toronto	lei.sun@utoronto.ca
Mahlet Tadesse	University of Pennsylvania	mtadesse@cceb.med.upenn.edu
Daniel Yekutieli	Tel Aviv University	yekutiel@post.tau.ac.il

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