Statistical and Applied Mathematical Sciences Institute
19 T. W. Alexander Drive
P.O. Box 14006
Research Triangle Park, NC 27709-4006
Tel: 919.685.9350 FAX: 919.685.9360
info@samsi.info

 

Opening Workshop of the SAMSI Program Genomes To Global Health:

Computational Biology Of Infectious Disease

September 19-22, 2004

 

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GENERAL INFORMATION

The Opening Workshop for the SAMSI Program on Genomes to Global Health: Computational Biology of Infectious Disease will be held on Sunday-Wednesday, September 19-22, 2004, at the Radisson Hotel Research Triangle Park (formerly the Governors Inn).  It will begin with tutorials and end with initial meetings of the working groups that will form the core of the year-long program. A major goal of this Opening Workshop is to frame issues to be addressed during the SAMSI program, and the workshop will be organized to facilitate achievement of this goal. In particular, input from all participants will be sought through a variety of mechanisms.

 

 ORGANIZING COMMITTEE

Lindsay Cowell (Duke Univ), Tom Kepler (Duke Univ) and Denise Kirschner (Univ of Michigan)

 

SCIENTIFIC ADVISORY COMMITTEE

Roy Anderson (Imperial College, London), Rustom Antia (Emory Univ), Carl Bergstrom (Univ of Washington), Arturo Casadevall (Albert Einstein College of Medicine), Carlos Castillo-Chavez (Arizona State Univ), Sunetra Gupta (Oxford Univ), Jun Liu (Harvard Univ), Alan Perelson (Los Alamos National Lab) and Man-Wah Tan (Stanford Univ). 

 

LOCAL ADVISORY COMMITTEE

William Atchley (NC State Univ), Tim Elston (UNC), Andrew Nobel (UNC), Scott Schmidler (Duke Univ) and Jeff Thorne (NC State Univ)

 

REGISTRATION

Registration information, including requests for financial support, should be submitted as soon as possible. The registration deadline is September 5, 2004.  In order to ensure your registration is correct, we ask that you:

Please make reservations at the Radisson as soon as possible. If you have a change in plans, individual room reservations must be cancelled 72 hours prior to arrival. Check-in is at 3:00 PM; check-out is 12:00 noon.

NOTE:  The Radisson is now fully booked on September 21.  The Wellesley Inn is the best alternative option.  Please visit the SAMSI housing page for contact information.

As it is difficult to control the temperature in the large conference rooms, we suggest you bring a light jacket or sweater with you.

 

 

PRELIMINARY SCHEDULE

Sunday -- September 19, 2004

Radisson Hotel RTP, Room H (3rd floor)

 

8:00-9:00 AM

Registration and Continental Breakfast

 
9:00-12:30 PM Mathematics and Statistics Tutorials:

 

9:00-9:45          Statistics & Data Analysis

                                Tom Kepler, Duke University

 

9:45-10:30        Bioinformatics and Genomics

                         Tom Kepler, Duke University

 

10:30-11:00      Coffee Break

 

11:00-11:45      Epidemiology

                         Alun Lloyd, North Carolina State University

 

11:45-12:30      Mathematical modeling & simulation

                         Tom Kepler, Duke University

 

12:30-1:30 PM

Lunch

 

1:30-5:00 PM

Biology tutorials:

 

1:30-2:30          Molecular Evolution

                          Jeff Thorne, North Carolina State University

 

2:30-3:00          Coffee Break

 

3:00-4:00          Microbiology

                          Denise Kirschner, University of Michigan

 

4:00-5:00          Immunology

                          Lindsay Cowell, Duke University

 

   

 

Monday -- September 20, 2004

Radisson Hotel RTP, Room H (3rd floor)

 

8:30-9:00 AM

Registration and Continental Breakfast

 
9:00-9:15 AM

Welcome

  • Jim Berger, SAMSI

  • Denise Kirschner, University of Michigan

  • Lindsay Cowell, Duke University

 

9:15-9:45 AM

Opening Address

  • Tom Kepler, Duke University

 

 

SESSION 1:  Biostatistics, Epidemiology and Public Health

Session Chair:  Andrew Nobel, University of North Carolina - Chapel Hill

 
9:45-10:45 AM

“Markov Models for Characterizing the Development of HIV Resistance Mutations”

Victor De Gruttola, Harvard School of Public Health

 

10:45-11:00 AM Coffee Break
11:00-12:00 PM

“Stochastic Models and Analytic Issues for Interventions against Pandemic Influenza”

M. Elizabeth Halloran, Emory University  

 
12:00-1:00 PM

Lunch

 
1:00-2:00 PM

“From Immunome to Vaccine: Using Immunoinformatics to Design New Vaccines”

Anne De Groot, Brown University 

 

2:00-3:00 PM

“New Paradigm for Management of Tropical Diseases”

Ayoade Oduola, World Health Organization

 
3:00-3:30 PM

Coffee Break

 

 

Session Chair:  Tim Elston, University of North Carolina - Chapel Hill

 
3:30-4:30 PM

DISCUSSION:  Mathematical challenges in biostatistics and public health

 

Discussion Leaders

  • Alun Lloyd, North Carolina State University

  • Anthony So, Duke University

 
4:30-5:30 PM

Introductions to poster session

 

6:30-8:30 PM Poster session and reception at SAMSI (+)

Continuous shuttle service for the Poster Session will be provided by Carolina Livery.  The first shuttle will depart from the Radisson at 6:25pm and the last shuttle will leave SAMSI at 8:45pm.  Poster Presenters:  A shuttle will leave at 5:45pm to bring you to SAMSI for set-up. 

 (+) SAMSI will provide poster presentation boards.  The board dimensions are 4 ft. wide by 3 ft. high.  They are tri-fold with each side being 1 ft. wide and the center 2 ft. wide.  Please make sure your poster fits the board.  Posters may not be taped to the walls or blackboards. 

Tuesday -- September 21, 2004

Radisson Hotel RTP, Room H (3rd floor)

 

8:30-9:00 AM

Registration and Continental Breakfast

 

 

SESSION 2:  Microbiology, Microbial Ecology & Evolution, Microbial Genomics

Session Chair:  Andrew Nobel, University of North Carolina - Chapel Hill

 
9:00-10:15 AM

"Use of repetitive DNA in Helicobacter pylori for persistence in human hosts"

Martin Blaser, New York University

 

10:15-10:45 AM

Coffee Break

 
10:45-12:00 PM

"Predicting the Future Evolution of Human Influenza Viruses"

Walter Fitch, University of California-Irvine

 

12:00-1:00 PM

Lunch

 

 

Session Chair:  Scott Schmidler, Duke University

 
1:00-2:00 PM

"Bioinformatic Methods for Virulence Gene Prediction in Microbial Pathogens"

Joanna Fueyo, IBM

 
2:00-3:00 PM

"A Mathematical Model for Nutrient Depletion and Detachment in a Heterogeneous Biofilm"

Jorge Velasco-Hernandez, Instituto Mexicano del Petroleo

 
3:00-3:30 PM

Coffee Break

 
3:30-4:30 PM

"Modeling Long-Term HIV Dynamics and Antiviral Treatment with Consideration of Pharmacokinetics, Adherence and Drug Susceptibility"

Hulin Wu, University of Rochester

 

4:30-5:30 PM

Panel Discussion: "Mathematical challenges in microbiology"

 

Discussion Leader

  • Denise Kirschner, University of Michigan

 

 

Wednesday--September 22, 2004

Radisson Hotel RTP, Room H (3rd floor)

 

8:30-9:00 AM Continental Breakfast

 

SESSION 3:  Immunology

Session Chair:  Alun Lloyd, North Carolina State University

 
9:00-10:00 AM

"Monoclonal Antibodies in the Treatment of Disease:  Modeling How They Couple Target Cell to Killer Cells"

Byron Goldstein, Los Alamos National Laboratory

 
10:00-11:00 AM

"MHC Polymorphism and Peptide Diversity"

Rob De Boer, Utrecht University

 
11:00-11:30 AM

Coffee Break

 
11:30-12:30 PM

"A Bioinformatics Approach to the Antigen Presentation and Processing Pathways"

Can Kesmir, Utrecht University

 

12:30-1:30 PM

Lunch

 

 

Session Chair:  Scott Schmidler, Duke University

 
1:30-2:30 PM

Panel Discussion:  "Mathematical Challenges in Immunology and Systems Biomedicine"

 

Discussion Leaders

Lindsay Cowell, Duke University

Denise Kirschner, University of Michigan

 
2:30-3:00 PM

Coffee Break

 
3:00-3:15 PM

Charge to the participants and final words

Tom Kepler, Duke University

 
3:15-5:00 PM

Working Group Formation and Planning

 

 

 

Local Information (Hotels, etc.)

 

 

Computational Biology Program Page

 

 

Program Poster (pdf file)

 

 

SAMSI Home Page

 

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